(S)-1-Boc-piperazine-2-carboxylic acid

(S)-1-Boc-piperazine-2-carboxylic acid - Names and Identifiers

Name	(S)-1-Boc-piperazine-2-carboxylic acid
Synonyms	S-4-Boc-Piperazine-3-carboxylicacid S-1-BOC-piperazidine-2- formic acid (S)-1-Boc-piperazine-2-carboxylic acid (S)-4-Boc-Piperazine-3-carboxylic acid 1-(tert-butoxycarbonyl)piperazine-2-carboxylic acid (2S)-1-tert-butoxycarbonylpiperazine-2-carboxylic acid (S)-Piperazine-1,2-dicarboxylic acid 1-tert-butyl ester (2S)-1-[(tert-butoxy)carbonyl]piperazine-2-carboxylic acid 1,2-Piperazinedicarboxylic acid, 1-(1,1-dimethylethyl) ester, (2S)-
CAS	159532-59-9
InChI	InChI=1/C10H18N2O4/c1-10(2,3)16-9(15)12-5-4-11-6-7(12)8(13)14/h7,11H,4-6H2,1-3H3,(H,13,14)/t7-/m0/s1

(S)-1-Boc-piperazine-2-carboxylic acid - Physico-chemical Properties

Molecular Formula	C10H18N2O4
Molar Mass	230.26
Density	1.193±0.06 g/cm3(Predicted)
Melting Point	243-247 ºC (DEC.)
Boling Point	371.8±37.0 °C(Predicted)
Flash Point	178.6°C
Vapor Presure	1.5E-06mmHg at 25°C
pKa	2.90±0.20(Predicted)
Storage Condition	2-8°C(protect from light)
Refractive Index	1.495

(S)-1-Boc-piperazine-2-carboxylic acid - Risk and Safety

Hazard Symbols	Xi - Irritant
Risk Codes	36/37/38 - Irritating to eyes, respiratory system and skin.
Safety Description	26 - In case of contact with eyes, rinse immediately with plenty of water and seek medical advice.

(S)-1-Boc-piperazine-2-carboxylic acid - Introduction

(S) acid is an organic compound having the following properties:

1. Appearance: colorless to light yellow solid.
2. Melting Point: about 70-72 ℃.
3. Solubility: Soluble in common organic solvents, such as ethanol, dimethylformamide and dichloromethane.

(S)-acid is widely used in the field of organic synthesis, the main uses include:
1. As an enantioselective reagent:(S)-acid can be used to synthesize enantioselective compounds, especially chiral drugs and chiral ligands.
2. As a protecting group:(S)-Boc Group in acid can be used as a reagent for protecting hydroxyl group and amine group to prevent non-specific reaction in the reaction.
The preparation method of
(S)-acid can be carried out through the following steps:
1. First, piperazine reacts with dichloroformamide to generate (2-chloroacetamido)pyrimidine.
2. Then, (2-chloroetacamido) pyrimidine reacts with (S)-2-hydroxypropionate to generate (S)-pyrimidine.

About safety information:
1. (S)-(acid) Avoid inhalation and contact with skin and eyes during storage and handling.
2. Operation should take good ventilation measures.
3. Use should wear protective gloves, protective glasses and protective clothing.
4. If the skin or eyes are touched, rinse immediately with water and seek medical help.
5. Please read the safety data form of the chemical carefully, and use the compound in accordance with the correct operating procedures and safety measures.

Last Update：2024-04-09 21:01:54